Effect of CoenzymeQ10 Prophylaxis on Neurosensory Disturbances and Altered Sensation Following Orthognathic Surgery: A Triple-Blind Randomized Controlled Trial and Biochemical Assessment

Status

Unknown

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20231115001

Enrollment

Registered

2023-11-15

Start date

2023-12-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing orthognathic surgery using BSSO technique CoenzymeQ10 Neurosensory disturbances Peripheral nerve injuries Oxidative stress Neuroinflammation

Interventions

CoQ10 oral supplement 300 mg/day will be prescribed to participants for 2 weeks prior to the surgery.,Placebo tablets will be provided by Pharmacy Unit, Dental hospital, Faculty of Dentistry, Chiang M

Experimental Dietary Supplement,Placebo Comparator No treatment

CoenzymeQ10 300 mg,Placebo group

Eligibility

Sex/Gender

All

Age

No minimum to 45 Years

Inclusion criteria

Inclusion criteria: 1.Non-growing patients (below 45 years old) 2.Healthy status (American Society of Anesthesiologist (ASA) Class I ) 3.Undergoing orthognathic surgery using BSSO technique

Exclusion criteria

Exclusion criteria: 1.History of allergy to medications used in this study 2.History of maxillofacial trauma 3.History of neurosensory disturbance of mandible area 4.History of any neurodegenerative diseases 5.Currently receiving any kind of herbs and supplements 6.Being unable to attend follow-up appointments

Design outcomes

Primary

Measure	Time frame
CoenzymeQ10 level operative day, 1- week after surgery ELISA KIT,Malondialdehye level preoperative, operative day, 1- week after surgery Microplate fluorescence assay,TNF-alpha preoperative, operative day, 1- week after surgery western blot analysis,SOD-2 level preoperative, operative day, 1- week after surgery western blot analysis,NRF2 level preoperative, operative day, 1- week after surgery western blot analysis,NF-kappaB preoperative, operative day, 1- week after surgery western blot analysis	—

Measure

Time frame

CoenzymeQ10 level operative day, 1- week after surgery ELISA KIT,Malondialdehye level preoperative, operative day, 1- week after surgery Microplate fluorescence assay,TNF-alpha preoperative, operative day, 1- week after surgery western blot analysis,SOD-2 level preoperative, operative day, 1- week after surgery western blot analysis,NRF2 level preoperative, operative day, 1- week after surgery western blot analysis,NF-kappaB preoperative, operative day, 1- week after surgery western blot analysis

—

Secondary

Measure	Time frame
Objective neurosensory perception preoperative, 1-week, 1-month, 3-month, 6-month Two-point discrimination,Brush stroke directions, Light touch/contact detections and Pin-prick test ,Subjective neurosensory perception preoperative, 1-week, 1-month, 3-month, 6-month questionnaires	—

Countries

Thailand

Contacts

Public ContactNapatsorn Imerb

Chiang Mai University

napatsorn.i@cmu.ac.th6653944440

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026