Mild to Moderate Asthma Exacerbation Lung function Admission rate Exhaled nitric oxide Budesonide nebulization Mild to Moderate Asthma Exacerbation PEFR Admission rate FENO Budesonide nebulization
Conditions
Interventions
Conventional treatment of acute mild to moderate asthma exacerbation plus high dose budesonide 3 mg total nebulization,Conventional treatment in acute mild to moderate asthma exacerbation with placebo
Placebo Comparator Drug,Placebo Comparator Drug
High dose steroid nebulization,Placebo NSS nebulization
Sponsors
Research Panyananthaphikkhu Chonprathan Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 60 years 2. Asthma diagnosis by a physician 3. Mild to moderate Asthma exacerbation ( from Thai asthma guideline 2022) from 3.1 no alteration of consciousness 3.2 Respiratory rate < 30 times/min 3.3 No accessory muscle used or no abdominal paradoxical 3.4 Oxygen saturation not less than 90% 3.5 Pulse rate less than 120 beats per minute
Exclusion criteria
Exclusion criteria: 1. Alteration of consciousness 2. Respiratory rate > 30 times/min 3. Accessory muscle used or abdominal paradoxical 4. Oxygen saturation less than 90% 5. Pulse rate less than 120 beats per minute 6. Using of systemic corticosteroid in last 2 weeks 7. Acute diseases that affect asthma exacerbation ( Pneumonia, Heart failure, Lung cancer) 8. Pregnancy 9. COVID-19 infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analog scale 1 day 1 to 10,Exhaled Nitric oxide 1 day ppb | — |
Secondary
| Measure | Time frame |
|---|---|
| Peak expiratory flow rate 1 day Litre per minute | — |
Countries
Thailand
Contacts
Public ContactChirawat Chiewchalermsri
Srinakharinwirot University
Outcome results
None listed