To compare the intubation rate, 28-day mortality rate, hospital length of stay, and ventilator free day between high-flow nasal and noninvasive ventilation in patient suspected sepsis with respiratory failure in emergency department. High-flow nasal cannula, noninvasive ventilation, acute respiratory failure
Conditions
Interventions
Patients with suspected sepsis and ARF received HFNC,Patients with suspected sepsis and ARF received NIV
Treatment,Treatment
HFNC-group,NIV-group
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients who visit Ramathibodi ED with suspected sepsis and acute respiratory failure defined by at least one of these: respiratory rate > 25, SpO2 <90, PaO2-to-FiO2 ratio <300 or clinical presentation of respiratory distress (such as accessory muscles use or abdominal paradox)
Exclusion criteria
Exclusion criteria: 1. Patients needed for immediate intubation 2. Patients presented with cardiac arrest 3. Patients who referred from other department or hospital with high-flow nasal cannula or noninvasive ventilation 4. Patients with a do-not-intubate order 5. Patients on home positive airway pressure (PAP) therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intubation rate 48 hours risk ratio | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day mortality rate 28 days risk ratio,Hospital length of stay 28-day median,Ventilator-free day at day 28 28-day mean | — |
Countries
Thailand
Contacts
Public ContactChuenruthai Angkoontassaneeyarat
Mahidol University
Outcome results
None listed