Acute decompensated heart failure Acute decompensated heart failure, furosemide, loop diuretic, urine sodium, urine output
Conditions
Interventions
Record urine sodium to adjust furosemide dose according to the protocol,Record urine output to adjust furosemide dose according to the protocol
Experimental Other,Active Comparator Other
urine sodium arm,urine output arm
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age more than 18-year-old with hospital admission with the principal diagnosis of acute decompensated heart failure within 24 hours of the hospital visit. 2. Presence of at least one symptoms and signs of volume overload: orthopnea, paroxysmal nocturnal dyspnea, jugular venous distension, lung crepitation.
Exclusion criteria
Exclusion criteria: 1. Hydrochlorothiazide, acetazolamide, or tolvaptan use within 48 hours prior to the enrollment period 2. Systolic blood pressure < 90 mmHg or mean arterial pressure < 65 mmHg 3. Inotrope or vasopressor usage 4. Glomerular function rate < 30 ml/min/1.73m2 5. Use of renal replacement therapy or ultrafiltration 6. Exposure to intravenous contrast agents anticipated within the next 72 hours 7. Need for invasive mechanical ventilation 8. Concurrent diagnosis of an acute coronary syndrome 9. History of cardiac transplantation and/or ventricular assist device 10. Pregnant or currently breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total urine output at 72 hours of the study period 72 hours after the intervention mL | — |
Secondary
| Measure | Time frame |
|---|---|
| Freedom from congestion at 72 hours of the study period Within 72 hours after the intervention Symptoms and physical examination,Length of hospital stay Until discharge from admission days,Composite end point at 1 month after hospital discharge 1 month Death from any cause, Heart failure rehospitalization, Need for renal replacement therapy | — |
Countries
Thailand
Contacts
Public ContactChuti Burana
King Chulalongkorn Memorial Hospital
Outcome results
None listed