Introduction to the research problem and its significance. Evidences from Western and Asia Pacific countries shows that colorectal cancer (CRC) screening could reduce the incidence and mortality of CRC. According to many guidelines recommendation, the CRC screening should be started at the age of 50 in the general population. Currently, colonoscopy is the most effective screening tool. Because it has a high accuracy in a cancer and polyp detection and colonoscopy also provides the ability to pe
Conditions
Interventions
FIT cutoff of 5 micrograms per gram to define FIT positivity for high-risk subjects and the cutoff of 20 micrograms per gram to define FIT positivity for non-high-risk subjects. (FIT5/20)
, The other
Screening,Screening
FIT5/20,FIT20
Sponsors
The Royal College of Physicians of Thailand
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria 1. All participant with age 50-75 years 2. Participant with age 40-75 if participant has the first degree relative of CRC before age 50 3. Provide inform consent to participate in the study
Exclusion criteria
Exclusion criteria: Exclusion criteria 1. Symptoms that suspected gastrointestinal cancer such as hematochezia, bowel habit change, or weight loss 2. Had been diagnosed colorectal cancer or inflammatory bowel disease 3. There are severe comorbid diseases that limits life-expectancy such as end stage of cancer, heart disease or lung disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| positive predictive value (PPV) After fecal immunochemical test was analyzed by OC-SENSOR PLEDIA, total processing about 7 minites. OC-SENSOR PLEDIA, Eiken Chemical | — |
Secondary
| Measure | Time frame |
|---|---|
| the number needed to screen (NNS) to detect AN through FIT 2 weeks, After pathology reported. Colonoscopy | — |
Countries
Thailand
Contacts
Public ContactAssist. Prof. Satimai Aniwan
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed