Emergence agitation (EA) is common in pediatric patients after general anesthesia, particularly in high-risk operations like strabismus surgery. EA is characterized by disturbances in a child'
Conditions
Interventions
Group ketofol will receive ketamine 0.25 mg/kg with propofol 1 mg/kg in total volume 10 ml.,Group saline will receive a normal saline total volume of 10 ml.
Active Comparator Drug,No Intervention No treatment
ketofol group,saline group
Sponsors
Research Affairs, Faculty of Medicine, KKU
Eligibility
Sex/Gender
All
Age
2 Years to 5 Years
Inclusion criteria
Inclusion criteria: Pediatric patient Age from 2 to 5 years Schedule for elective strabismus surgery under general anesthesia American Society of Anesthesiologists (ASA) physical status class I, II Parents give written informed consent
Exclusion criteria
Exclusion criteria: Patients with a history of allergy to propofol or ketamine Unable to follow the study protocol Developmental delay Neurological or psychological disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emergence agitation On arrival at PACU and then every 15 minutes until 60 minutes Emergence agitation score | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score every 15 minutes until 60 minutes FLACC score,Nausea and vomiting at PACU The events of nausea and vomiting,Hypotension every 2 minutes after receiving the intervention until 10 minutes Blood pressure,Bradycardia every 2 minutes after receiving the intervention until 10 minutes Heart rate,Oxygen desaturation every 2 minutes after receiving the intervention until 10 minutes Oxygen saturation,Emergence times from time form discontinues anesthetic agent to awake time,PACU times from admit PACU until discharge from PACU time,Parent satisfaction before discharge from PACU numeric rating scale from 0 to 10 | — |
Countries
Thailand
Contacts
Public ContactPrathana Wittayapairoch
Srinagarind Hospital
Outcome results
None listed