Drug-resistant epilepsy Mozart K.448 Drug-resistant epilepsy patients Electroencephalography Interictal epileptiform discharge Quantitative Electroencephalography Heart rate variability Video EEG monitoring
Conditions
Interventions
The sonata for two pianos in D major, K448(Mozart K.448) chapter 1,Quiet environment
Experimental Device,No Intervention No treatment
Mozart K.448,Quite environment
Sponsors
Chulalongkorn Comprehensive Epilepsy Center of Excellence
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age more than 18 years old 2.Drug-resistant epilepsy was diagnosed 3.Stable antiseizure medication dose for 1 months before inclusion
Exclusion criteria
Exclusion criteria: 1.Patients who refused to participate in the research 2.Patients who cannot do an EEG according to the 10-20 principle, such as patients undergoing cranial surgery. 3.Patients with hearing impairment 4.Patient was diagnosed with epilepsy caused by progressive neurological disease such as Rasmussen's encephalitis, mitochondrial disorders, inborn error of metabolism, autoimmune-associated epilepsy, etc. 5.Patients who tend to be unable to tolerate listening to Mozart K.448, such as those with intellectual disabilities and accompanying behavioral problems. 6.In the first 4-hour EEG recording during the first night of the study, there were fewer than 10 interictal epileptiform discharges. 7.The patient has a history of irregular heart rhythm known as atrial fibrillation. 8.The patient has a history of having a permanent pacemaker (PPM) implanted.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interictal epileptiform discharge During intervention Pearson chi-square test or Fisher exact test | — |
Secondary
| Measure | Time frame |
|---|---|
| Quantitative EEG During intervention Pearson chi-square test or Fisher exact test,Heart rate variability During intervention Pearson chi-square test or Fisher exact test | — |
Countries
Thailand
Contacts
Public ContactSomjet Tosamran
King Chulalongkorn Memorial Hospital
Outcome results
None listed