20 to 40-year-old Transgender men requiring Testosterone treatment Testosterone, Transgender men, Transmen, Female-to-male, Epigenetics, Sirtuin-1, Alu Methylation, SAM/SAH ratio, Metabolism, Age-related disease
Conditions
Interventions
Sponsors
Ratchasapisek Sompoch grant
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: - 20 to 40-year-old healthy Transgender men who come to follow up at the Transgender clinic at King Chulalongkorn Memorial Hospital - Transmen who have not received testosterone - Transmen who have not undergone sex reassignment surgery or ovarian surgery - agree to participate in research by signing - Thai nationality - able to communicate in Thai
Exclusion criteria
Exclusion criteria: - Have a history of hormonal disorders - Have NCDs such as Diabetes, CVD, Cancer, Stroke, Renal failure, Chronic respiratory disease - Received any drugs known to affect hormone metabolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sirtuin-1 expression at 0, 4, 8, 12 weeks after Testosterone treatment ELISA | — |
Secondary
| Measure | Time frame |
|---|---|
| Alu methylation at 0, 4, 8, 12 weeks after Testosterone treatment Pyrosequencing,SAM/SAH ratio at 0, 4, 8, 12 weeks after Testosterone treatment ELISA,Metabolic outcome at 0, 12 weeks after Testosterone treatment Blood pressure, CBC, Lipid profile, Liver function test, fasting blood sugar, HbA1C | — |
Countries
Thailand
Contacts
Public ContactPunika Panichaya
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University
Outcome results
None listed