PPH rate among term pregnancy scheduled for elective cesarean delivery Postpartum hemorrhage, carbetocin, stepwise administration
Conditions
Interventions
On the day prior to the surgery, blood samples were collected at the time of intravenous access for a complete blood count. Demographic data was recorded in the case record form. Carbetocin was prepar
s request. The pulse rate and blood pressure were recorded by the anesthesia team before the operation, before drug administration, and then 2 minutes after administration, and every 5 minutes until 3
Experimental Drug
50 mcg carbetocin
Sponsors
Siriraj Routine to research (R2R) unit
Eligibility
Sex/Gender
Female
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.term singleton pregnancies 2. age at least 20 years old 3. schedule for undergoing elective cesarean sections at Siriraj Hospital
Exclusion criteria
Exclusion criteria: 1.patient has risk of harm from Carbetocin including those with Carbetocin allergies, underlying cardiovascular, liver, kidney, epilepsy, migraine, and asthma conditions. 2.Obese women with a BMI above 35 kg/m2 3.high-risk pregnancies that could affect uterine contractility, such as preeclampsia, placenta previa, placenta accrete spectrum, polyhydramnios, uterine structural abnormalities, hematologic underlying diseases 4.those who received tocolytic drugs within the previous 24 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of postpartum hemorrhage after cesarean delivery calculated blood loss | — |
Secondary
| Measure | Time frame |
|---|---|
| efficacy of carbetocin after cesarean delivery percentage of uterine contraction within first dose,pregnancy outcomes and complication 24 hours after cesarean delivery adverse drug reaction, pulse and blood pressure change, Hb and Hct level, blood transfusion, ICU admission, maternal and neonatal morbidity/mortality,Factors influence additional dose of uterotonic drug after cesarean delivery logistic regression analysis | — |
Countries
Thailand
Contacts
Public ContactTripop Lertbunnaphong
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed