A Single-center, Randomnized, Evaluator-blinded, Active-controlled Study to evaluate the effectiveness and Safety of Neuramis deep for Correct in Patients with lip and perioral wrinkles.

Status

Unknown

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20231008002

Enrollment

Registered

2023-10-08

Start date

2023-11-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male and Female age 20 years or older with perioral wrinkle severity scale (PWSS) of moderate to severe Perioral wrinkle

Interventions

Neuramis deep injection at lip and perioral area,Restylane kysse injection at lip and perioral area.

Experimental Procedure/Surgery,Active Comparator Procedure/Surgery

Neuramis deep ,Restylane kysse

Eligibility

Sex/Gender

All

Age

20 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Male and Female age 20 years old or older 2. Perioral wrinkle severity scale (PWSS) of moderate to severe level 3. Consent in participate in the project

Exclusion criteria

Exclusion criteria: 1. Previous laser treatment 6 months prior 2. Previous mesotherapy treatment 3 months prior 3. Previous botulinum toxin 6 months prior 4. Previous biostimulator injection 3 months prior 5. History of allergy to anesthesia

Design outcomes

Primary

Measure	Time frame
PWSS 3 months PWSS score measurement	—

Secondary

Measure	Time frame
PWSS 1 month PWSS score measurement ,PWSS 2 months PWSS score measurement ,GAIS 1, 2, 3, 6 months GAIS measurement by physician,Wrinkle and Texture 0, 1, 2, 3, 6 months Antera,Volume change 0, 1, 2, 3, 6 months Vectra program	—

Countries

Thailand

Contacts

Public ContactPitchaya Maneeprasopchoke

Siriraj, Mahidol university

wonajan@gmail.com0897891703

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026