Sepsis and septic shock patients Sepsis Septic shock RBC transfusion Hemoglobin level Restrictive blood transfusion Liberal blood transfusion
Conditions
Interventions
Patients who received RBC transfusion when their Hemoglobin level lower than 7 g/dL,Patient who received RBC transfusion when their Hemoglobin (Hb) level between 7 to 9 g/dL
Treatment,Treatment
Restrictive transfusion group,Liberal transfusion group
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients who were diagnosed with sepsis and septic shock, as indicated by an ICD-10 code 2. Adult patients (at least 18 years old) 3. Admitted between between 1st March 2018 to 31st January 2022 4. Met the criteria for sepsis or septic shock diagnosis according to the Surviving Sepsis Campaign 2016 5. Received PRC transfusion within 3 days after sepsis or septic shock diagnosis
Exclusion criteria
Exclusion criteria: 1. Clinically important bleeding (which means overt bleeding accompanied by a decrease in systolic blood pressure of more than 20 mmHg, an increase in pulse rate of more than 20 beats per minute, or a drop in hemoglobin levels of more than 2 g/dL) 2. Acute coronary syndrome 3. Overt gastrointestinal bleeding 4. Immediate post-operative patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality 28 days after sepsis/septic shock was diagnosed Death or survive | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospital stay Duration of hospital admission Days,Acute kidney injury From sepsis/septic shock was diagnosed until hospital discharge or death Occurred or not occurred,Pulmonary edema From sepsis/septic shock was diagnosed until hospital discharge or death Occurred or not occurred,ARDS From sepsis/septic shock was diagnosed until hospital discharge or death Occurred or not occurred,Cardiac arrest From sepsis/septic shock was diagnosed until hospital discharge or death Occurred or not occurred,Bowel ischemia From sepsis/septic shock was diagnosed until hospital discharge or death Occurred or not occurred | — |
Countries
Thailand
Contacts
Public ContactChairat Permpikul
Faculty of Medicine, Siriraj Hospital
Outcome results
None listed