Patients with symptomatic knee osteoarthritis at Kellgren &
Conditions
Interventions
Active Comparator Other,Active Comparator Other
Adipocyte-derived mesenchymal stem cells (ADSCs),Hyaluronic acid
Sponsors
National Research Council of Thailand (NRCT)
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with symptomatic knee osteoarthritis at Kellgren & Lawrence stage II that discontinued the use of nonsteroidal anti-inflammatory drugs (NSAIDs) for at least 2 weeks
Exclusion criteria
Exclusion criteria: 1. Patients with secondary osteoarthritis. 2. Patients with a history of significant trauma, such as fractures of the knee and malformation of the bones. 3. Patients with cancer. 4. Patients with swollen, red, or hot knees. 5. Patients experiencing worsening pain or side effects from the procedure. 6.Patients with diabetes (DM), immunocompromised conditions. 7. Patients who have previously received stem cell therapy. 8. Patients with abnormal blood clotting or taking anticoagulant medications. 9. Pregnant women and breastfeeding mothers. Please note that this revision clarifies the criteria for selecting and excluding participants in the randomized controlled trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical improvement 0,1,3,6 month WOMAC score | — |
Secondary
| Measure | Time frame |
|---|---|
| radiographic improvement 0,1,3,6 month MRI ultrasound | — |
Countries
Thailand
Contacts
Public ContactPonthep tangkanjanavelukul
University
Outcome results
None listed