the ovarian reserve change using anti-mullerian hormone levels before and 6 weeks after undergoing hysterectomy with bilateral salpingectomy ovarian reserve anti-mullerian hormone hysterectomy Coenzyme Q10
Conditions
Interventions
oral 300 mg of Coq10 supplement for two weeks before undergoing hysterectomy with bilateral salpingectomy,The placebo was an identical soft gelatin capsule as the intervention arm.
oral placebo was g
Placebo Comparator Drug,Placebo Comparator Drug
CoQ10,placebo
Sponsors
Ramatibodi hospital, Mahidol university
Eligibility
Sex/Gender
Female
Age
25 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. The women age between 25 to 45 years old 2. Diagnosed with leiomyoma or adenomyosis scheduled for hysterectomy with bilateral salpingectomy 3. Provided signed informed consent
Exclusion criteria
Exclusion criteria: 1. History of ovarian surgery 2. Anticipated ovarian cystectomy 3. Hormonal use within 3 months before surgery 4. Known allergies to CoQ10 or starch 5. Suspected malignancy 6. Drug use that interacts with CoQ10 , for example; warfarin or statin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| percentage AMH change 2 weeks before surgery and 6 weeks after surgery percentage AMH change between pre- and post-operative level | — |
Secondary
| Measure | Time frame |
|---|---|
| safety profile after two weeks course of intervention or placebo side effects report by participants,Liver and renal function 6 weeks after complete course of intervention or placebo SGOT, SGPT, BUN, creatinine levels | — |
Countries
Thailand
Contacts
Public ContactArtitaya Singwongsa
Reproductive Endocrinology and Infertility Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Outcome results
None listed