One of the most common symptoms of knee osteoarthritis is pain and loss of joint flexibility. The bone could be deformed if the symptom is not treated properly. Lily leaves are commonly used for pain relief by using as an ingredient in Traditional Thai medicine. Lily leaves were heated and used as herbal medicine to wrap around the knee thereby reducing the inflammation and pain. Therefore, the spray from lily leaves extract is expected to be effective in supplementing the medical treatment i
Conditions
Interventions
All Subjects will receive standard treatment of knee osteoarthritis plus the spray as the add-on. 48 randomized participants of placebo arm will use a spray-base product without an active ingredient
Placebo Comparator No treatment,Active Comparator Drug,Experimental Other
Spray Base,Indomethacin,Lily Herbal Spray
Sponsors
Thai Traditional Medical Knowledge Fund
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Knee OA stage 2,3 2. Chronic knee pain (at least 1 month) 3. No acute inflammation 4. Be able to walk witout caregiver/walking stick 5. No history of an accident/falls causing knee injuries for at least 1 month
Exclusion criteria
Exclusion criteria: 1. Knee OA with CNS and/or spinal cord malfunction 2. Knee OA from bone trauma, bone fractures 3. OA with multiple joint pain
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain 7 days and 3 weeks after intervention Koos/WOMAC/VAS | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical knee function 7 days and 3 weeks after intervention WOMAC/ Koos/Gait spped/30s Chair Stand Test | — |
Countries
Thailand
Contacts
Public ContactJeerang Wongtrakul
Chiangmai University
Outcome results
None listed