Anterior cruciate ligament injury patients which underwent anterior cruciate ligament reconstruction surgery. Post-operative pain, ACL reconstruction
Conditions
Interventions
Etoricoxib 120 mg tablet oral q 24 hours + NSS 5 mL IV q 12 hours,Parecoxib 40 mg IV q 12 hours + placebo tablet oral q 24 hours
Experimental Drug,Active Comparator Drug
Etoricoxib,Parecoxib
Sponsors
Faculty of Medicine, Prince of Songkla University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: The patients diagnosed as anterior cruciate ligament injury aged 18-50 years old who scheduled for arthroscopic ACLR.
Exclusion criteria
Exclusion criteria: 1. Patient who schedules for bone-patellar tendon-bone autograft ACL reconstruction 2. Allergy to acetaminophen, aspirin, sulfonamide, NSAIDs or opioids 3. History of dyspepsia, peptic ulcer, or abnormal bleeding 4. History of ASCVD (History of diagnosis ACS, clinical likely ACS) 5. History of CKD 6. History of asthma or COPD because selective COX-inhibitor induce spasm 7. History of cerebrovascular disease 8. History of peripheral arterial disease 9. Patients who have Kratom or Marijuana used or substance abuse 10. Patients who anesthesiologist concerns the risk of general anesthesia (GA) is higher than spinal anesthesia; hence, they prefer to use spinal anesthesia rather than general anesthesia 11. Pre-operative abnormal EKG or laboratory result e.g., high Cr clearance, abnormal coagulogram
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score Every 4 hours from post-op until 48 hours Questionnaire, VNRS | — |
Secondary
| Measure | Time frame |
|---|---|
| Amount of rescue analgesic Within 24 hours post-op Medical record,Time to first dose of rescue analgesic Within 24 hours post-op Medical record,Side effect Within 48 hours post-op Questionnaire | — |
Countries
Thailand
Contacts
Public ContactPhatklao Thanavirun
Department of Orthopedics, Faculty of Medicine, Prince of Songkla University
Outcome results
None listed