Lactation failure in mothers of preterm newborn Domperidone, Breast Milk, Preterm Mother, Galactagogue
Conditions
Interventions
Prescribed 6 weeks of domperidone drug,Prescribed 4 weeks of domperidone drug and 2 weeks of placebo,Prescribed 6 weeks of placebo
Domperidone 6 weeks,Domperidone 4 weeks Then Placebo 2 weeks,Placebo 6 weeks
Sponsors
Prapokklao Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Mothers who have neonate in GA < 37 weeks 2. > 18 years old Mothers 3. Communicable in Thai or English 4. Acceptance to be participants
Exclusion criteria
Exclusion criteria: 1. Cannot breast feeding (eg. drug abuse, alcoholism, HIV infected etc.) 2. Mammoplasty with periareolar incision or Nipple and areola transplanted 3. Prolactin-releasing tumor 4. Allergy to Domperidone 5. History of Heart diseases or Abnormal ECG (QT Prolong, Bradycardia, Ventricular arrhythmia, Sudden cardiac arrest) 6. Currently on Antiarrhythmic drugs and drugs interfering to the Domperidone mechanism (eg. azole- drugs, antifungals, macrolides, monoamine oxidase inhibitors) 7. Chronic illness, Moderate to severe liver impairment (Child-Pugh >=7) , Gastric abnormalities, Severe renal impairment (serum creatinine > 6 mg/100 mL, i.e. > 0.6 mmol/L) 8. Smoking during pregnancy 9. Hypo-/Hyperkalemia or Hypomagnesemia 10. Unavailable to feeding in every 2-3 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Breast Milk Volume 6 weeks Breast Milk Volume | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects 6 weeks Porportion of side effects,Neonatal outcome 6 weeks Weight, Number of defecation, Number of waking up, Jaundice,Maternal outcome 6 weeks depression propotions, Decreased weight | — |
Countries
Thailand
Contacts
Public ContactPaphada Raksasuk
Prapokklao hospital
Outcome results
None listed