Osteoarthritis of knee Osteoarthritis knee nsaids patch transdermal dexamethasone
Conditions
Interventions
Esflurbiprofen patch,Placebo patch
Experimental Drug,Placebo Comparator No treatment
NSAIDs patch,Duoderm patch
Sponsors
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 55-80 years old 2. KL 3-4 3. Primary Total Knee Arthroplast 4. Willing to join research
Exclusion criteria
Exclusion criteria: 1. Allergic to Steroids, NSAIDs, Morphine, Paracetamol, Gabapentinoids, or Codeine 2. GFR less than 30 mL/min/1.73m2 3. DM with HbA1C > 8 mg% 4. Previous Steroids used regularly or continuous over 1 month 5. cannot anaesthetised by spinal block alone 6. not willingly to join the research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS 2 wk, 6 wk, 3 mo point 0-10 | — |
Secondary
| Measure | Time frame |
|---|---|
| MO consumption POD1,2,3 mg,minimum VAS during a day POD4,5,6,7 point,time to minVAS POD4,5,6,7 hours,Knee circumference 2wk,6wk,3mo centimeters,Knee flexion angle 2wk,6wk,3mo degree,KOOS 2wk,6wk,3mo point,Adverse effects POD3-2wk present | — |
Countries
Thailand
Contacts
Public ContactKhanawan Tubsrinuan
Resident
Outcome results
None listed