To study the effectiveness of ZR spray (test group, 30), comparison to Diclofenac spray (standard control group, 30) in primary osteoarthritis of knee patients. On second follow up, after day 14, participants in control group (1) and test group (1) were dropout due to infect the Coronavirus disease (COVID-19). Zanthoxylum rhetsa, Osteoarthritis, VAS, WOMAC, Pain
Conditions
Interventions
Spraying diclofenac spray on knee pain for 14 days (day 1 to day 14) and stopped spraying on day 15.,Spraying ZR spray on knee pain for 14 days (day 1 to day 14) and stopped spraying on day 15.
Active Comparator Drug,Experimental Drug
Diclofenac spray,ZR spray
Sponsors
Mae Fah Luang University
Eligibility
Sex/Gender
All
Age
45 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Male and female between 45 to 85 years of age. 2. One side of knee pain more than 3 months, pain score from 3 to 10 assessed by 0 to 10 visual analog score (VAS). 4. Joint stiffness and crepitation sound. 5. Diagnosed with primary OA knee by Orthopedics doctor with based on the American College of Rheumatology 's clinical and radiographic finding and classified to 1 to 4 grading based on Kellgren and Lawrence radiographic. 6. Treated by only intake acetaminophen or NSAIDs or muscle relaxant or sysadoa.
Exclusion criteria
Exclusion criteria: 1. Body mass index (BMI) over 32 kg/m2. 2. Participants with hypersensitivity on essential oil or perfume. 3. Participants in among pregnancy, breastfeeding, cancer, infectious diseases, and disability. 4. Participants who undergoing alternative treatment with massage, acupuncture, etc or physical therapy. 5. Participants who were treated by intake or inject corticosteroids prior research 3 months, or treated by hyaluronic injection prior research 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score day 0, after day 7, after day 14 Independent t-test, Mann-Whitney U test, Paired Samples t-test, or Wilcoxon Signed Ranks test | — |
Secondary
| Measure | Time frame |
|---|---|
| WOMAC index score day 0, after day 7, after day 14 Independent t-test, Mann-Whitney U test, Paired Samples t-test, or Wilcoxon Signed Ranks test | — |
Countries
Thailand
Contacts
Public ContactChureeporn Imphat
School of Integrative Medicine, Mae Fah Luang University
Outcome results
None listed