Effect of ondansetron on the incidence of bradycardia-induced hypotension during pneumoperitoneum in patients undergoing laparoscopic cholecystectomy

Effect of ondansetron on the incidence of bradycardia-induced hypotension during pneumoperitoneum in patients undergoing laparoscopic cholecystectomy : RCT

Status

Unknown

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230905008

Enrollment

260

Registered

2023-09-05

Start date

2023-09-10

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pneumoperitoneum between laparoscopic cholecystectomy can present bradycardia-induced hypotension via vagus nerve bradycardia-induced hypotension

Interventions

after induction : inject ondansetron 8 mg iv,after induction : inject NSS 4 ml IV

Experimental Drug,Experimental Drug

ondansetron 8 mg iv,NSS 4 ml

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: patient who was schedual for laparoscopic cholecystectomy ASA physical status 1-2

Exclusion criteria

Exclusion criteria: 1. abnormal EKG : QT prolong 2. acute cholecystitis 3. bradycardia hypotension before pneumoperitoneum 4. History on selective serotonin reuptake inhibitor 5. drug allergy : ondansetron

Design outcomes

Primary

Measure	Time frame
incidence of bradycardia-induced hypotension intraoperative Vital sign	—

Secondary

Measure	Time frame
bradycardia or hypotension intraoperative vital sign	—

Countries

Thailand

Contacts

Public ContactWorapot Apinyachon

Faculty of Medicine Ramathibodi Hospital, Mahidol University

ome-worapot@hotmail.com0948203223

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026