Combined inspiratory muscle training and home-based pulmonary rehabilitation in patient with interstitial lung disease: a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230905001

Enrollment

Registered

2023-09-05

Start date

2023-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patient with interstitial lung disease Interstital lung disease, Pulmonay rehabilitation, Inspiratory muscle training

Interventions

IMT protocol is interval-based program with loaded breathing for 20 minutes. IMT setting start at 30% of PImax and the titrate 10% every 2 weeks, total 8 weeks(IMT setting 60% of PI max). For pulmonar

Active Comparator Device,Sham Comparator Device

IMT + Pulmonary rehabilitation,Sham IMT + Pulmonary rehabilitation

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age 18 or above years old 2. Interstitial lung disease diagnosed by pulmonologist 3. no exacerbation in the past 3 months 4. Modified Medical Research Council dyspnea scale 2 or more 5. No supplemental oxygen therapy needed

Exclusion criteria

Exclusion criteria: 1.Unstable cardiac condition in the past month (unstable angina, myocardial infarction, symptomatic severe aortic stenosis, unstable cardiac arrhythmias, decompensated heart failure) 2. Other pulmonary disease that might affect outcome (recent pneumonia, pulmonary tuberculosis, , chronic obstructive pulmonary disease, asthma, bronchiectasis, lung cancer, pleural effusion, pneumothorax) 3.Need supplemental oxygen therapy during rest or exercise 4. Disability in musculoskeletal or neurological system causing unable to walk 5. Undergone structured exercise program during past 12 months

Design outcomes

Primary

Measure	Time frame
Respiratory muscle strength 4, 8, 24 weeks PImax, PEmax	—

Secondary

Measure	Time frame
Functional capacity 4, 8, 24 weeks 6 minute walk distance,Quality of life 4, 8, 24 weeks SGRQ,Dyspnea 4, 8, 24 weeks Modified Medical Research Council Dyspnea Scale (mMRC),Pulmonary function 24 weeks Spirometry, lung volume study, diffusing capacity for carbon monoxide (DLCO),Anxiety and depression 4, 8, 24 weeks HADS	—

Countries

Thailand

Contacts

Public ContactNawapat Kluabwang

Faculty of medicine Siriraj hospital, Mahidol university

nawapat.kw@gmail.com0876601388

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026