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Efficacy of Vaginal Progesterone for Maintenance Therapy in Arrested Preterm Labor: A Randomized Controlled Trial

Efficacy of vaginal progesterone for maintenance therapy in arrested preterm labor: A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20230901006
Enrollment
80
Registered
2023-09-01
Start date
2022-11-19
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preterm labor at gestational age of 24 weeks to 33 weeks and 6 days successfully inhibited with Nifedipine as an acute phase tocolysis (arrested preterm labor) Preterm labor

Interventions

400 micrograms of vaginal progesterone uses as maintenance tocolysis on the day of recruitment until gestational age of 37 completed week,No Maintenance tocolysis used
Experimental Drug,No Intervention No treatment
400 micrograms of vaginal progesterone,No treatment

Sponsors

Hatyai hospital
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Pregnant women presented with preterm labor at gestational age of 24 completed weeks to 33 weeks and 6 days

Exclusion criteria

Exclusion criteria: lethal fetal anomaly dead fetus in utero non-reassuring fetal status preeclampsia with severe features unstable maternal vital signs chorioamnionitis patient allergic to progesterone or progestrogen multifetal gestations placenta previa cervical os open more than 4 cm history of cervical cerclage in this pregnancy history of vaginal progesterone used in this pregnancy due to others indication for example ; short cervix

Design outcomes

Primary

MeasureTime frame
Latency days from the day presented with preterm labor to the day of delivery Unpaired student T-test

Secondary

MeasureTime frame
Gestational age at delivery Days,Birth asphyxia 1, 5 minutes after birth Apgar score,NICU admission after delivery Yes or no,Low birthweight at delivery Grams

Countries

Thailand

Contacts

Public ContactRaksina Nuprom

Hatyai hospital

raksina.nup@gmail.com66869577836

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026