In this single-arm, prospective controlled interventional trial, a total of 165 KOA patients were recruited based on American College of Rheumatology (ACR) criteria.2 KOA patients aged 50 to 80, whose serum vitamin D levels were below 30 ng/mL were the study'
Conditions
Interventions
Patients were administered a weekly dosage of vitamin D2 (40,000 IU) (eldecalcitol). During the first- and sixth-month visits, data on clinical parameters such as knee pain, physical disability, muscl
Experimental Dietary Supplement
Vitamin D (eldecalcitol)
Sponsors
National Research Council of Thailand (N42A650217)
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Knee osteoarthritis patients aged 50 to 80, whose serum vitamin D levels were below 30 ng/mL were the study's intended participants.
Exclusion criteria
Exclusion criteria: Participants who had had recently undergone knee surgery or who had a history of malignant chronic diseases, such as advanced liver or renal disease, arthritis, protracted knee injury, persistent knee infection, inflammation, or who had used vitamin D supplements within the previous month were excluded. Remarkably, patients who were lost to follow-up or who received treatment beyond clinical palliations fulfil the withdrawal criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum LC3A levels Baseline and 6 months ELISA | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum 25(OH)D levels Baseline and 6 months Chemiluminescent immunoassay,Clinical parameters Baseline and 6 months Chemiluminescent immunoassay | — |
Countries
Thailand
Contacts
Public ContactWanvisa Udomsinprasert
Faculty of Pharmacy, Mahidol University
Outcome results
None listed