Polycystic ovary syndrome (PCOS) in infertile women who seeking infertility treatment with in vitro fertilization (IVF) PCOS, DNA methylation, exosome, follicular fluid, epigenetics, CYP19A1
Conditions
Interventions
Female age 18-42 years old who diagnosed as PCOS according to International Evidence-Based Guideline for the Assessment and Management of Polycystic ovary syndrome 2018,Female age 18-42 years old wh
Basic Science,Basic Science
PCOS,Normal ovarian responder
Sponsors
Program Management Unit for Human Resources & Institutional Development,Research and Innovation (PMU-B)
Eligibility
Sex/Gender
Female
Age
18 Years to 42 Years
Inclusion criteria
Inclusion criteria: 1. Female age 18-42 year old 2. Diagnosed as PCOS according to International Evidence-Based Guideline for the Assessment and Management of Polycystic ovary syndrome 2018
Exclusion criteria
Exclusion criteria: 1. Diagnosed as any cancer 2. Diagnosed as endometriosis 3. Diagnosed as PCOS mimicking diseases such as Cushing syndrome, Adult onset adrenal hyperplasia, thyroid disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA methylation level in follicular fluid exosome at the end of recruitment Methylation specific PCR | — |
Secondary
| Measure | Time frame |
|---|---|
| DNA methylation level in cumulus cell at the end of recruitment Methylation specific PCR | — |
Countries
Thailand
Contacts
Public ContactBoonyakiat Thammasate
Department of Obstetric and Gynecology, Faculty of Medicine, Chulalongkorn University
Outcome results
None listed