Development of Computerized Multicomponent Cognitive Stimulation for Improving Cognitive Functions in Older Adults with Mild Cognitive Impairment: A Multimodal Investigation Using Neuropsychological and EEG/ERP Assessment

A Randomized Controlled Trial of Computerized Multicomponent Cognitive Stimulation for Improving Cognitive Functions in Older Adults with Mild Cognitive Impairment: A Multimodal Investigation Using Neuropsychological and EEG/ERP Assessment

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230829004

Enrollment

Registered

2023-08-29

Start date

2023-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Older adults with mild cognitive impairment (MCI) mild cognitive impairment MCI

Interventions

The interventional program has adopted from group-CST for MCI with 10 sessions (Gomez-Soria et al., 2020) and computerized CST (Djabelkhir-Jemmi et al., 2018

Djabelkhir-Jemmi et al., 2017) and group-CST principle (Spector, Orrell, Davies, &amp

Woods, 2001

Spector et al., 2003

Yates et al., 2017) and adapting CST to other cultures (Aguirre et al., 2010

Aguirre et al., 2014). Specifically, the program also adopted audio-visual temporal discrimination training to improve multisensory integration (Setti et al., 2014) that is included in sessions. The

Experimental Behavioral,Active Comparator Behavioral,No Intervention No treatment

Computerized Multicomponent Cognitve Stimulation,Computerized Cognitive Stimulation,Control group

Eligibility

Sex/Gender

All

Age

60 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) Thai native speakers. 2) Age more than 60 years. 3) The performances in objective memory impairment are based on the Montreal Cognitive Assessment (MoCA) and The Clinical Dementia Rating (CDR) scores 4) Right-handed according to the Edinburgh Handedness Inventory. 5) Normal color vision according to the Ishihara Plate Test. 6) No chronic illness, deafness, blindness, or major neurological disorder. 7) Not demented 8) Able to read with comprehension 9) Able to use computer devices.

Exclusion criteria

Exclusion criteria: 1) Participants diagnosed with dementia. 2) Participants with systemic illness. 3) Participants refusal to participate.

Design outcomes

Primary

Measure	Time frame
Learning and memory End of the intervention Paired associate learning test,Executive End of the intervention Wisconsin card sorting test,Language End of the intervention Verbal fluentcy test,Psychomotor End of the intervention Reaction time tests (Simple and Choice),Visuospatial skills End of the intervention Mental rotation and Corsi block tapping tests,Multisensory integration End of the intervention Sound-Induced Flash Illusion (SIFI) test,EEG End of the intervention alpha, theta, beta, and delta,ERP End of the intervention N100, P200, P300, N400 and P600,Global cognitive function End of the intervention Montreal Cognitive Assessment,Emotions (Depression) End of the intervention Geriatric Depression Scale,Emotions (Anxiety) End of the intervention State-Trait Anxiety Inventory	—

Measure

Time frame

Learning and memory End of the intervention Paired associate learning test,Executive End of the intervention Wisconsin card sorting test,Language End of the intervention Verbal fluentcy test,Psychomotor End of the intervention Reaction time tests (Simple and Choice),Visuospatial skills End of the intervention Mental rotation and Corsi block tapping tests,Multisensory integration End of the intervention Sound-Induced Flash Illusion (SIFI) test,EEG End of the intervention alpha, theta, beta, and delta,ERP End of the intervention N100, P200, P300, N400 and P600,Global cognitive function End of the intervention Montreal Cognitive Assessment,Emotions (Depression) End of the intervention Geriatric Depression Scale,Emotions (Anxiety) End of the intervention State-Trait Anxiety Inventory

—

Secondary

Measure	Time frame
Quality of Life End of the intervention Quality of Life and Activities of Daily Life Index tests	—

Countries

Thailand

Contacts

Public ContactKhanitin Jornkokgoud

College of Research methodology and Cognitive Science, Burapha University

khanitin.j@gmail.com0801881681

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026