Comparison of silver diamine fluoride and fluoride varnish on caries prevention in patient with head and neck radiation therapy

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230826001

Enrollment

Registered

2023-08-26

Start date

2024-04-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Silver Diamine Fluoride (SDF) contains SDF 38 percent in water solution (255,000 ppmAg, 44,800 ppmF per 1 ml). Local application on teeth by dentist every 6 months.,Fluoride varnish contains sodium fl

Experimental Drug,Active Comparator Drug

Silver Diamine Fluoride,Sodium fluoride

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Head and neck cancer patients who have completed radiotherapy more than 1 month and within 3 months - Age 18 year or more - Complete dental treatment before study enrollment - Have at least 5 teeth

Exclusion criteria

Exclusion criteria: - Incapable of dental evaluation due to limited mouth opening - Allergic to silver - Presence of oral mucositis - Received head and neck radiation more than 1 course - Using fluoride mouth rinse

Design outcomes

Primary

Measure	Time frame
Radiation caries 2 years international caries detection and assessment system (ICDAS) index	—

Secondary

Measure	Time frame
caries 2 years Decayed, Missing, and Filled Surfaces (DMFS) index ,caries 2 years Decayed, Missing, and Filled Teeth (DMFT) index	—

Countries

Thailand

Contacts

Public ContactPipop Saikaew

Mahidol University

pipop045@gmail.com66624974698

Outcome results