Sedation level Sevoflurane, conscious sedation, Intensive Care Units
Conditions
Interventions
Before starting sedation, all patients were pain control patients with a target behavioral pain scale of less than 6 or a numeric rating scale of less than 3. Sevoflurane was titrated via Anaconda-S t
s method, end tidal sevoflurane concentration will be increased or decreased by 0.1 in the
following patient depending on the previous patient'
s response. The maximum end-tidal sevoflurane
concentration target is 1.4, according to the manufacturer'
s recommendations. During sedation, if patients'
hypotension is defined as mean arterial pressure (MAP) below 65 mmHg will start vasopressor or inotropic
agents are to keep MAP of more than 65 mmHg.
Experimental Drug
Sponsors
Ramathibodi Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adult patients age more than and equal to 18 years old. RASS > 1 and need sedation. Patient on a mechanical ventilator for at least 12 hours in medical or surgical intensive care units
Exclusion criteria
Exclusion criteria: Patients who have a history or family history of malignant hyperthermia. Patients who have evidence of raised intracranial pressure. Patients with low tidal volumes (<200 ml) and one-lung ventilation.patients who have persistent bronchopleural fistula despite chest tube drainage. Patients with epidural or regional analgesia Patients who receive vasopressor > 0.1 mcg/kg/min of norepinephrine-equivalent dose. Patients who lack of commitment to ongoing critical care treatment. Patients whose medication uses a nebulizer. Patients cannot inform consent. Pregnancy Patients with pulmonary disease who have a PF ratio<200. Patients who have APACHE scores> 20.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED 50 ED95 30 minutes RASS | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of intensive care unit stay within 1 year Days,Duration of ventilator day 28 days Days,Incidence of delirium 28 days Percents,Hemodynamic variables 30 minutes Numeric ,Respiratory variables 30 minutres Numeric | — |
Countries
Thailand
Contacts
Public ContactChawika Pisitsak
Ramathibodi Hospital
Outcome results
None listed