An association between mitochondrial dynamic and cell death markers in peripheral blood mononuclear cell and non-alcoholic steatohepatitis with significant liver fibrosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20230824010

Enrollment

Registered

2023-08-24

Start date

2022-03-30

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

To evaluate an association between mitochondrial dynamics and cell death markers from PBMCs and the presence of NASH with significant fibrosis among patients with NASH or non-alcoholic fatty liver disease (NAFLD) Non-alcoholic fatty liver disease (NAFLD) Metabolic syndrome Mitochondria dynamic function Magnetic resonance imaging (MRI) MR elastography Peripheral blood mononuclear cell (PBMC) Apoptosis Mitophagy Inflammatory cytokines

Interventions

Non-alcoholic steatohepatitis (NASH) with significant liver fibrosis (F2-4).,Non-alcoholic steatohepatitis or Non-alcoholic fatty liver disease (NAFLD/NASH) patients without significant liver fibrosi

Basic Science,Basic Science

F2-4 group,F0-1 group

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: (i) age more than 18 years (ii) diagnosed with metabolic syndrome according to NCEP III criteria (iii) schedule for bariatric surgery (iv) history of alcohol drinking less than 10 g/day in female and 20g/day in male in the past 12 months.

Exclusion criteria

Exclusion criteria: (i) presence of other conditions that may be associated with hepatic steatosis identified by history, physical examination, and laboratory investigation (ii) the presence of infectious or autoimmune liver disease (iii) having renal dysfunction (estimated glomerular infiltration rate by Chronic Kidney Disease Epidemiology Collaboration method < 60 mL/min/1.72m2; (iv) pregnancy or breastfeeding and (v) patients unable to obtain informed consent.

Design outcomes

Primary

Measure	Time frame
Correlation of mitochondrial 12 months Association between mitochondrial dynamics and cell death markers from PBMCs and the presence of NASH with significant fibrosis among patients with NASH or non-alcoholic fatty liver disease (NAFLD).	—

Secondary

Measure	Time frame
Compare the difference 12 months mitochondria dynamic function test	—

Countries

Thailand

Contacts

Public ContactThanaput Kunlayawutipong

Faculty of Medicine, Chiang Mai University

sk_129.mla@hotmail.com053936120

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026