Using HOWO ointment for post-laser wound care after fractional Er:YAG laser resurfacing in the treatment of hand rejuvenation

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230824005

Enrollment

Registered

2023-08-24

Start date

2023-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy patients who have wrinkles on the dorsal hand at level 2 or higher, according to the Dorsal Hand Wrinkling Scale HOWO ointment, Fractional Erbium:YAG, Erbium, Fractional Ablative Laser, Post laser care, wound care, Hand Rejuvenation

Interventions

The skincare formulation composed of 100% natural extracts, such as crocodile oil, turmeric, Centella asiatica, Chinese herbs, lotus seeds, sesame oil, and natural bee propolis. It can treat wounds, b

Active Comparator Other,Active Comparator Other

HOWO,Petroleum jelly

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: - Healthy - age 40-70 - wrinkle on the dorsal hand at level 2 or higher, according to the Dorsal Hand Wrinkling Scale

Exclusion criteria

Exclusion criteria: - Female participants who are planning to conceive, currently pregnant, or breastfeeding. - Inflamed skin, psoriasis, vitiligo in active stage, sunburn, or other uncontrolled skin conditions in the laser treatment area, or poorly controlled active infections. - skin laser treatment or dermal filler injection in the area to be treated with lasers within 6 months. - Intense Pulsed Light (IPL) treatment or chemical peeling in the area to be treated with lasers within 4 weeks. - History of taking oral retinoid within 6 months. - History of allergic reactions to medications or components present in the HOWO ointment. - History of keloids or hypertrophic scars. - History of light-sensitive rashes or are taking photosensitive drugs.

Design outcomes

Primary

Measure	Time frame
skin erythema day 1,2,3,5,8,15,45 5-point grading score	—

Secondary

Measure	Time frame
skin color baseline, day 1,2,3,5,8,15,45 Chromometer,Trans-epidermal water loss baseline, day 1,2,3,5,8,15,45 Tewameter,Edema day 1,2,3,5,8,15,45 5-point grading score,Pain score day 1,2,3,5,8,15,45 visual analog score assessed by patients(0-10)),Itching score day 1,2,3,5,8,15,45 visual analog score assessed by patients(0-10),hand wrinkle baseline, day 1,2,3,5,8,15,45 Global Aesthetic Improvement scale (GAIS), Indentation index from Antera3D	—

Measure

Time frame

skin color baseline, day 1,2,3,5,8,15,45 Chromometer,Trans-epidermal water loss baseline, day 1,2,3,5,8,15,45 Tewameter,Edema day 1,2,3,5,8,15,45 5-point grading score,Pain score day 1,2,3,5,8,15,45 visual analog score assessed by patients(0-10)),Itching score day 1,2,3,5,8,15,45 visual analog score assessed by patients(0-10),hand wrinkle baseline, day 1,2,3,5,8,15,45 Global Aesthetic Improvement scale (GAIS), Indentation index from Antera3D

—

Countries

Thailand

Contacts

Public ContactMarisa Pongprutthipan

Faculty of Medicine, Chulalongkorn University

dr_marisa@yahoo.com66827814958

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026