Patients with a history of infraorbital darkening diagnosed by dermatologist at least 1 year Infraorbital darkening, Q-switched 1064-nm Nd:YAG laser, fractional Q-switched laser, neocollagenesis, infraorbital rejuvenation, infraorbital volume
Conditions
Interventions
Q-switched NdYAG laser have specific wavelength targeting on melanosomes, narrow pulse width of nanosecond and low fluence adjustment, the QSNYL with its selective photothermolysis and photomechanic
Experimental Device
multi-pulsed Q-switched 1064-nm Nd:YAG laser
Sponsors
none
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: - Healthy patient with a history of infraorbital darkening diagnosed by dermatologist at least 1 year - Fitzpatrick skin type II to IV
Exclusion criteria
Exclusion criteria: - Signs of active infection or inflammation around the eyes - Diseases related to infraorbital darkening - Active systemic severe medical diseases/ photosensitivity such as liver cirrhosis, thalassemia, systemic lupus erythematosus and dermatomyositis - Drug-induced hyperpigmentation such as hydroxychloroquine, chloroquine, gold or zidovudine - History of any ocular or periocular surgery e.g. blepharoplasty or treatment of fat herniation - History of abnormal wound healing process such as poor controlled diabetes mellitus or smoking - History of atopy - Pregnancy and lactation - Immunocompromised host/status - Sleep disorders such as sleep disturbance or narcolepsy - Use of oral retinoids within 6 months - Use of nonsteroidal antiinflammatory drugs, steroids, anticoagulants, blood thinning agents and topical whitening agents within 1 months. - Previous laser treatment, chemical peels or transepidermal whitening agents within 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| skin lightness baseline, 1 month after final session of laser Chromameter | — |
Secondary
| Measure | Time frame |
|---|---|
| Infraorbital volume baseline, 1 month after final session of laser Croma infraorbital hollow assessment ,Elevation and depression volume baseline, 1 month after final session of laser Antera 3D,skin color (red,blue,green) baseline, 1 month after final session of laser Chromameter,Improvement scale 1 month after final session of laser 6-graded improvement scale (deteriorating, worsening, neutral, no improvement, poor, fair, good, and excellent),Patient's satisfaction score 1 month after final session of laser 4-point scale (dissatisfied, fair slightly satisfied, intermediately satisfied, and very satisfied) | — |
Countries
Thailand
Contacts
Public ContactMarisa Pongprutthipan
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed