Persistent pulmonary hypertension PPHN
Conditions
Interventions
subject will be given sildenafil and its efficacy will be studied over 3 days,subject will be given bosentan and its efficacy will be studied over 3 days
Active Comparator Drug,Active Comparator Drug
Sponsors
self
Eligibility
Sex/Gender
All
Age
1 Days to 10 Days
Inclusion criteria
Inclusion criteria: 1. less than 10 days of age of either gender greater than 34 weeks of gestational age echocardiographic findings according to operational definations 2. new born with sign and symptoms of PPHN not related to any secondary cause
Exclusion criteria
Exclusion criteria: 1. babies with congenital heart disease except atrieal septal defect other cyanosis diseases and PPHN caused by pneumonia or meconium aspiration ventriculo septal defect 2. babies with active seiures pneumothorax and other congenital anomalies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| drug efficacy 1 year tricuspid regurgitation jet pressure from echo | — |
Secondary
| Measure | Time frame |
|---|---|
| drug capability 1 year oxygen dependency | — |
Countries
Pakistan
Contacts
Public Contactabdul chtha
Children's hospital ,Lahore
Outcome results
None listed