Degenerative change of the lumbar spine can cause lumbar stenosis or lumbar nerve root compression. The Spine Patient Outcomes Research Trial (SPORT) reported that surgery has a better therapeutic effect than non-surgical treatment, both in the field of pain reduction and healthy function of organs. Conventional lumbar laminectomy usually involves the extensive dissection of soft tissue, ligament, and bone, typically bringing on moderate to severe pain, especially in the first few days after t
Conditions
Interventions
Ketorolac 30mg iv before induction phase of general anesthesia ,Dexamethasone 8mg iv before induction phase of general anesthesia
Experimental Drug,Active Comparator Drug
Ketorolac,Dexamethasone
Sponsors
Self
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75 year-old 2. Scheduled elective lumbar spine decompressive laminectomy not more than 3 levels 3 .ASA physical status of between I and III
Exclusion criteria
Exclusion criteria: -Known allergy to ketorolac, acetaminophen, dexamethasone or morphine -History of previous lumbar surgery -History of renal impairment(creatinine clearance <30mm/min) -Opioid drug abuse -Current chronic anticoagulant or antiplatelet therapy -Contraindication to general anesthesia and inability to give informed consent -Poor control diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measure assessed amount of morphine consumed. at PACU,12,24 and 48hour after surgery morphine comsumed measure by IV PCA( mg ) | — |
Secondary
| Measure | Time frame |
|---|---|
| Measure assessed pain score. at PACU,12,24 and 48hour after surgery VAS (0-10 scores) | — |
Countries
Thailand
Contacts
Public ContactTerdsak Phonchan
Khonkaen University
Outcome results
None listed