Type 2 Diabetes mellitus Vitamin D Insufficiency Type 2 Diabetes mellitus Vitamin D Insufficiency
Conditions
Interventions
Participants with at least one edentulous site with adequate bone dimensions for dental implant placement. The implant sites are required to have at least 4 months of healing post-extraction, with no
Healthy patients,Type 2 diabetes mellitus with normal serum 25(OH)D level,Type 2 diabetes mellitus with low serum 25(OH)D level
Sponsors
Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Healthy patient or patient diagnosed with type 2 diabetes mellitus with edentulous site with adequate bone dimensions for dental implant placement 2. The implant sites are required to have at least 4 months of healing post-extraction, with no previous ridge augmentation or bone grafting
Exclusion criteria
Exclusion criteria: 1. Systemic diseases that may affect wound healing 2. Cancer 3. Bone metabolic disease such as osteoporosis 4. Under treatment using bisphosphonate 5. Regular use of medications that could affect healing 6. Irradiation in head and neck area 7. Untreated periodontal disease 8. Smoking habit 9. Pregnancy or lactation, planned pregnancy 10. Immunocompromised or under immunosuppressive drug treatment 11. Addiction to alcohol or drugs 12. History of kidney stones 13. Abnormal sensitivity to vitamin D or hypervitaminosis D
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Marginal bone loss at 1,3,6,9 and 12 months follow-up mm | — |
Secondary
| Measure | Time frame |
|---|---|
| Implant stability at 3 months follow-up ISQ value,Bone-related biological marker and inflammatory cytokines 1,2,3,6 and 12 months follow-up pg/ml | — |
Countries
Thailand
Contacts
Public ContactPichchaporn Ruerattanawong
Chulalongkorn University
Outcome results
None listed