Vitamin D status and response to supplementation in very preterm infants: A prospective cohort study

Incidence of vitamin D deficiency and temporal changes in vitamin D levels in very preterm or low birth weight infants: a prospective, single center study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20230725007

Enrollment

126

Registered

2023-07-25

Start date

2023-06-13

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary objective -Incidence of vitamin D deficiency in preterm infants GA less than 32 weeks or birth weight less than 1,500 grams Secondary objectives - To determine maternal and neonatal factors associated with vitamin D deficiency in preterm infants - To monitor and follow ALP, calcium, phosphorus, vitamin D level and neonatal growth -To determine association between vitamin D level and incidence of bronchopulmonary dysplasia -To determine association between vitamin D level and incid

Interventions

Vitamin D level less than 12 ng/ml is severe vitamin D deficiency, D level 12-20 ng/ml is vitamin D deficiency , Vitamin D level more than 20-100 ng/ml is vitamin D sufficient, and vitamin D more th

Health Services Research

Vitamin D level

Eligibility

Sex/Gender

All

Age

1 Days to No maximum

Inclusion criteria

Inclusion criteria: Preterm infants GA < 32 weeks or birth weight < 1,500 grams, born at Siriraj hospital and born to the law authorizes parents of age not under 18-year-old to give informed consent.

Exclusion criteria

Exclusion criteria: 1.Congenital anomaly or severe malformation e.g., trisomy 13, trisomy 18 or life threatening 2.Newborn infants with abnormal calcium, phosphorus and vitamin D metabolism e.g., Digeorge syndrome 3.Newborn infants with congenital pulmonary and airway abnormality e.g., TE fistula, congenital pulmonary airway malformation or congenital diaphragmatic hernia

Design outcomes

Primary

Measure	Time frame
serum 25(OH)D 2 month-old serum 25(OH)D level	—

Secondary

Measure	Time frame
Maternal and neonatal factors accociated with vitamin D deficiency in preterm infants 2 month-old Medical record,Monitoring of ALP, calcium, phosphorus, vitamin D level and growth 2 month-old Medical record,Association between vitamin D level and incidence of bronchopulmonary dysplasia 2 month-old Medical record,Association between vitamin D level and incidence of respiratory distress syndrome 2 month-old Medical record	—

Measure

Time frame

Maternal and neonatal factors accociated with vitamin D deficiency in preterm infants 2 month-old Medical record,Monitoring of ALP, calcium, phosphorus, vitamin D level and growth 2 month-old Medical record,Association between vitamin D level and incidence of bronchopulmonary dysplasia 2 month-old Medical record,Association between vitamin D level and incidence of respiratory distress syndrome 2 month-old Medical record

—

Countries

Thailand

Contacts

Public ContactSuphawe Wasuanankun

Faculty of medicine Siriraj hospital, Mahidol university

Suphawe.uvwe@gmail.com094492954

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026