Comparison of plasma bupivacaine concentrations between ultrasound-guided anterior parasagittal oblique approach and posterior approach to quadratus lumborum block

Comparison of plasma bupivacaine concentrations between ultrasound-guided anterior parasagittal oblique approach and posterior approach to quadratus lumborum block : A Randomize single blind study.

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230717002

Enrollment

Registered

2023-07-17

Start date

2023-07-20

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Plasma bupivacaine concentrations in difference approach of quadratus lumborum block. Plasma bupivacaine concentrations, quadratus lumborum block

Interventions

Ultrasound-guided anterior parasagittal oblique approach to quadratus lumborum block with bupivacaine 150 mg and adrenaline (1:400,000),Ultrasound-guided posterior approach to quadratus lumborum block

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Patients undergoing open gynecologic surgery, 2.General anesthesia and quadratus lumborum block, 3.ASA Physical Status Classification status 1- 2

Exclusion criteria

Exclusion criteria: 1.Chronic pain syndrome, 2.Chronic kidney disease stage 3 - 5, 3.Liver impairments, 4.Coagulopathy and Thrombocytopenia, 5.Obesity, BMI more than 35

Design outcomes

Primary

Measure	Time frame
Plasma bupivacaine concentrations Before QLB with bupivacaine , after QLB with bupivacaine administration at 5 minutes, 10 minutes,30 minutes,45 minutes,1 hours , 2 hours, 6 hours, 24 hours Collect plasma bupivacaine from venous blood	—

Secondary

Measure	Time frame
Chronological changes of plasma bupivacaine concentrations Before QLB with bupivacaine , after QLB with bupivacaine administration at 5 minutes, 10 minutes,30 minutes,45 minutes,1 hours , 2 hours, 6 hours, 24 hours Collect plasma bupivacaine from venous blood,Pain score at rest and movement Immediate arrive at PACU and 1 hour after,post operation at 6hours , 24 hours Numeric Rating Scale 0-10,Total morphine consumption Immediate arrive at PACU and 1 hour after,post operation at 6hours , 24 hours Morphine doses (milligram),Postoperative nausea and vomiting Immediate arrive at PACU and 1 hour after,post operation at 6hours , 24 hours No, mild , moderate, severe ,Local Anesthetic Systemic Toxicity Immediate arrive at PACU and 1 hour after,post operation at 6hours , 24 hours No, Yes	—

Measure

Time frame

Chronological changes of plasma bupivacaine concentrations Before QLB with bupivacaine , after QLB with bupivacaine administration at 5 minutes, 10 minutes,30 minutes,45 minutes,1 hours , 2 hours, 6 hours, 24 hours Collect plasma bupivacaine from venous blood,Pain score at rest and movement Immediate arrive at PACU and 1 hour after,post operation at 6hours , 24 hours Numeric Rating Scale 0-10,Total morphine consumption Immediate arrive at PACU and 1 hour after,post operation at 6hours , 24 hours Morphine doses (milligram),Postoperative nausea and vomiting Immediate arrive at PACU and 1 hour after,post operation at 6hours , 24 hours No, mild , moderate, severe ,Local Anesthetic Systemic Toxicity Immediate arrive at PACU and 1 hour after,post operation at 6hours , 24 hours No, Yes

—

Countries

Thailand

Contacts

Public ContactLisa Sangkum

Faculty of Medicine Ramathibodi Hospital, Mahidol University

lisa.sangkum@gmail.com0989075899

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026