sarcopenia in cirrhotic patients sarcopenia, cirrhosis, exercise, branched-chain amino acide, BCAA, CPET, skeletal muscle index, SMI
Conditions
Interventions
adding branched-chain amino acid supplement with home-based exercise for 12 weeks
Experimental Dietary Supplement
adding branched-chain amino acid supplement with home-based exercise
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Any cause cirrhotic patient with CTP atleast 7 Sarcopenia by Computer Tomography scan
Exclusion criteria
Exclusion criteria: Severe comorbid disease: ESRD,uncontrol DM,COPD,CHF,ACS,cancer HIV infection, AIDS Liver or kidney transplant HCC beyond Milan Criteria History of TIPS Uncontrol ascites, EV, GV, Jaundice Hepatic encephalopathy Current alcohol drinking Hospitalization due to severe bacterial infection Receive BCAA within 6 months Severe orthopedic problems limiting possibility to exercise Pregnancy Patient refuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sarcopenia improvement 12 weeks Skeletal Muscle Index (SMI) | — |
Secondary
| Measure | Time frame |
|---|---|
| aerobic muscle function 12 weeks Cardio Pulmonary Exercise Test, 6-Minute Walk Test,frailty 12 weeks liver frailty index,severity of cirrhosis 12 weeks Model for End stage Liver Disease,Child Turcotte Pugh score,quality of life 12 weeks Thai SF-36 questionaire | — |
Countries
Thailand
Contacts
Public ContactNapakul Siripen
Thammasat University
Outcome results
None listed