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Effectiveness of concentrated growth factor and laser on inferior alveolar nerve injury and periodontal bone defect after mandibular impacted wisdom tooth extraction

Effectiveness of concentrated growth factor and laser on inferior alveolar nerve injury and periodontal bone defect after mandibular impacted wisdom tooth extraction

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20230704001
Enrollment
31
Registered
2023-07-04
Start date
2022-11-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

inferior alveolar nerve injury and periodontal bone defect after mandibular impacted wisdom tooth extraction Mandibular Impacted Wisdom Teeth, Inferior alveolar nerve injury, Distal Bone Defects , Concentrated Growth Factor, Lasers, Periodontal probe depth

Interventions

All patients were randomly divided into three groups: the control group, the concentrated growth factor group, and the laser group. The control group was treated with mecobalamin for 14 days, the conc
Active Comparator Drug,Experimental Procedure/Surgery,Experimental Radiation
mecobalamin ,concentrated growth factor,laser

Sponsors

Foshan Stomatological Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 43 Years

Inclusion criteria

Inclusion criteria: 1) patients were diagnosed with IAN injury after the Extraction of impacted mandibular wisdom teeth; 2) cbct or panoramic photograph showed that there was no significant teeth decay, alveolar bone resorption, or other jaw lesions in the distal part of the adjacent second molar; 3) the impacted wisdom teeth had no pericoronitis and no significant shadow at the root tip; 4) aged 18 years or over.

Exclusion criteria

Exclusion criteria: 1) complicated with severe cardiovascular diseases or blood system diseases; 2) having a periodontal disease in the distal part of the adjacent second molar before the operation; 3) taking drugs affecting bone or soft tissue healing before; 4) osteoporosis; 5) poor oral hygiene; and 6) smoking and drinking.

Design outcomes

Primary

MeasureTime frame
recovery of injured nerves 1 and 3 month after operation VAS and PP tests

Secondary

MeasureTime frame
regeneration of periodontal bone defect 1 and 3 month after operation periodontal probing depth

Countries

China

Contacts

Public ContactTAN JUN

Foshan Stomatological Hospital

2506879912@qq.com15838037931

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026