Concurrent chemoradiotherapy (CCRT) in locally advanced head and neck cancer (LAHNC) induced acute toxicities. Hydrogen gas, Hydrogen gas Inhalation, Concurrent chemoradiotherapy, CCRT, Locally advanced head and neck cancer, Acute toxicities
Conditions
Interventions
Hydrogen gas Inhalation Method: The patients will inhale hydrogen-oxygen mixed-gas, with flow rate 1.8 L/min (hydrogen:oxygen ratio is 2:1 (produced by Hycellvator ET100, Helix Japan Co.,Ltd.), throug
Experimental Device
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Loco-regional advanced stage HNC 2. Histologically-proven diagnosis of HNC 3. Eastern Cooperative Oncology Group (ECOG) performance status 0-2 4. Able to provide informed consent
Exclusion criteria
Exclusion criteria: 1. Distant metastasis or locoregional recurrence disease 2. Contraindications to RT or chemotherapy or Hydrogen gas inhalation 3. Previous head and neck irradiation 4. Previous head and neck surgery (except biopsy) 5. Patients with tracheostomy tube 6. Patients with respiratory disease e.g. asthma, COPD, Pneumonia, Lung cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of applications of Hydrogen gas inhalation At the end of CCRT Counting the number of applications of Hydrogen gas inhalation | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety of hydrogen gas inhalation During CCRT Descriptive,Acute CCRT toxicities During CCRT NCI CTC version 5.0 ,Tumor response At 3 months after end of CCRT RECIST Criteria | — |
Countries
Thailand
Contacts
Public ContactImjai Chitapanarux
Faculty of Medicine, Chiang Mai University
Outcome results
None listed