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Investigating the Role of Salivary Interleukin-40 Levels in Diagnosing Periodontal Diseases

Investigating the Role of Salivary Interleukin-40 Levels in Diagnosing Periodontal Diseases

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20230621001
Enrollment
120
Registered
2023-06-21
Start date
2022-05-03
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontally healthy Gingivitis Stage III Grade B periodontitis Periodontitis Gingivitis Saliva Interleukin-40 Interleukin-1 beta MMP-8

Interventions

Group S: 40 periodontally healthy patients were selected. These patients had no clinical loss of attachment (LOA) and no radiographic bone loss, the distance between the enamel-cementum junction and t
Diagnostic,Diagnostic,Diagnostic
S Group ,G Group ,P Group

Sponsors

Scientific Research Project Coordination Unit of the Akdeniz University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. who had not received periodontal treatment and had not taken antibiotics in the last six months, 2. who did not have any systemic diseases affecting periodontal health, 3. aged between 18 and 65, 4. who did not smoke, 5. who were not pregnant, 6. who had at least 20 teeth, 7. voluntarily agreed to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Those who have undergone periodontal treatment within the last 6 months for any reason, 2. Those who have used antibiotics in the last 6 months for any reason, 3. Those with any systemic disease known to affect periodontal health (heart disease, diabetes, blood diseases, etc.), 4. Those taking immunosuppressive medication, 5. Patients receiving chemotherapy or radiotherapy, 6. People with infectious diseases, 7. Pregnant women, 8. Smokers, 9. Those who do not want to participate in the survey

Design outcomes

Primary

MeasureTime frame
level of IL-40 in saliva after all saliva samples have been collected and analyzed We measured the clinical periodontal parameters and utilized the ELISA technique to detect the levels of IL-40 in the saliva samples.

Secondary

MeasureTime frame
level of IL-1 beta in saliva after all saliva samples have been collected and analyzed We measured the clinical periodontal parameters and utilized the ELISA technique to detect the levels of IL-1 beta in the saliva samples.,level of MMP-8 in saliva after all saliva samples have been collected and analyzed We measured the clinical periodontal parameters and utilized the ELISA technique to detect the levels of MMP-8 in the saliva samples.

Countries

Turkey

Contacts

Public ContactNezahat Kayar

faculty member

dishekimligi@akdeniz.edu.tr02423106969

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026