Combined Effects of Turmeric Supplementation and Strengthening Exercises on Knee Pain, Physical Function and Quality of Life among Knee Osteoarthritis Patients.

Combined Effects of Turmeric Supplementation and Strengthening Exercises on Knee Pain, Physical Function and Quality of Life among Knee Osteoarthritis Patients

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230615003

Enrollment

Registered

2023-06-15

Start date

2023-03-20

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthiritis Knee Osteoarthritides Knee Osteoarthritis Osteoarthritis of Knee Osteoarthritis of the Knee

Interventions

Participants will perform strengthening exercise (3 times per week for 12 weeks) with turmeric supplementation (1 capsule daily for 12 weeks),Participants will perform strengthening exercise (3 times

Experimental Dietary Supplement,Placebo Comparator Other

Turmeric supplementation + Strengthening Exercise (TE),Placebo + Strengthening Exercise (PE)

Eligibility

Sex/Gender

All

Age

35 Years to 80 Years

Inclusion criteria

Inclusion criteria: Male and female patients who sought physiotherapy treatment at Hospital Universiti Sains Malaysia Age between 35-80 years old Symptomatic Knee OA Bilateral or single knee OA Kellgren-Lawrence grades of II or III upon radiographic classification Active full range of knee movement BMI 18.5-29.9 kg/m2

Exclusion criteria

Exclusion criteria: Allergy to turmeric supplements or herbal medication Candidate for surgical procedure Secondary OA due to trauma, rheumatoid arthritis, hemophilia and surgery. Intra-articular steroid injection done within the 3 months period. Using corticosteroids Presents with heart, liver and renal failure BMI > 30kg/m2 Smoker

Design outcomes

Primary

Measure	Time frame
Visual Analogue Scale (VAS) pretest, mid-test(6th week) and post test (12th week) pain scale,Quality of life questionnaires-Malay version (WHOQOL-BREF) pretest, mid-test(6th week) and post test (12th week) Quality of life	—

Secondary

Measure	Time frame
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pretest, mid-test(6th week) and post test (12th week) are pain (5 items), stiffness (2 items), and physical function (17 items).,6-minute walking test (6MWT) pretest, mid-test(6th week) and post test (12th week) distance walked by patients	—

Countries

Malaysia

Contacts

Public ContactBAWANI RAMAKRISHNAN

UNIVERSITI SAINS MALAYSIA

crbawarny@student.usm.my0126547567

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026