Healthy condition cone mushroom functional snack protein cognitive processing stress immune healthy volunteers
Conditions
Interventions
Subjects receive the placebo product which has the same color and smell and looks like the functional snack.,Subjects receive the functional sanck contain low dose of functional protein derived cone-m
Placebo,low dose of the functional protein derived cone-mushroom,high dose of the functional protein derived cone-mushroom
Sponsors
FUNDAMENTAL FUND, Khon Kaen University
Eligibility
Sex/Gender
All
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Healthy volunteers between the ages of 45 and 60 years 2. Menopausal syndrome and menopausal syndrome (In the case of a postmenopausal woman, must complete Amenorrhea is not more than 5 years since 12 consecutive months of missed menstruation.) 3. A state of normal memory 4. Can read and write Thai languages
Exclusion criteria
Exclusion criteria: 1. Have severe underlying diseases that require continuous medication, including cardiovascular disease, respiratory disease, Nervous system disease, diabetes, hyperlipidemia, High blood pressure, kidney disease, liver disease (assessed by AST or ALT is 2 times higher than normal (AST > 64 U/L; ALT > 50 U/L), lung disease or allergy, immune system disease, Hematologic disease, cancer, gout or high uric acid levels. 2. Hysterectomy and/or Oophorectomy 3. Take a drug of Hypothalamic Pituitary Gonadal axis 4. Exposure to pesticides 1 week prior to joining the project 5. Drink more than 5 alcoholic beverages per day. 6. Smoking more than 10 cigarettes per day. 7. Pregnant or planning to become pregnant at the time of the study or are breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the change in cognitive processing, stress and immune Baseline, 6 week, and 12 week ERP, self evaluation form, and laboratory | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety parameters Hematology, Blood biochemical markers, Blood electrolytes, Hormones, Baseline, 6 week, and 12 week laboratory of hospital, Oxidative stress status; malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx) Baseline, 6 week, and 12 week laboratory of HHP&HP,Inflammation levels IL-6 and TNF Baseline, 6 week, and 12 week laboratory of HHP&HP,acetylcholinesterase (AChE), monoamine oxidase (MAO; total MAO) Baseline, 6 week, and 12 week laboratory of HHP&HP,CD4, CD8, CD19, NK cell, interferon gamma, phagocytic, DTH, antigen-specific antibody production, B cell T cells Baseline, and 12 week laboratory of HHP&HP, pulse wave velocity, pulse wave analysis Baseline, 6 week, and 12 week SphygmoCor and Electrocardiogram (ECG),No. of Lactobacillus spp., Bifidobacterium spp. in fecal sample Baseline and 12 week laboratory of HHP&HP,Working memory test Baseline, 6 week, and 12 week Computerized batteries test (CDR), MSQ score, Wellbeing index, Cerebral Blood Flow (CBF),Urinalysis Baseline, 6 week, and 12 week laboratory of hospital | — |
Countries
Thailand
Contacts
Public ContactSuparporn Muchimapura
Faculty of Medicine, Khon Kaen University
Outcome results
None listed