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Effects of high-intensity interval training combined with asparagus root extract supplementation on physiological changes of muscle and vascular, inflammatory biomarker and autonomic nervous function in overweight and obese people

Effects of high-intensity interval training combined with asparagus root extract supplementation on physiological changes of muscle and vascular, inflammatory biomarker and autonomic nervous function in overweight and obese people

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20230608004
Enrollment
72
Registered
2023-06-08
Start date
2022-07-18
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male or female aged 18-30 years Having body mass index more than 23.0 kg/m2 Practice exercise or sport training less than 75 min/week High intensity interval training Asparagus Vascular function Muscle thickness Obesity

Interventions

Participants in the control group will be asked to maintain their daily physical activity and dietary intake for 12 weeks.,Participants in the HIIT group will be asked to perform home-based exercise p
No Intervention No treatment,Active Comparator Behavioral,Experimental Dietary Supplement,Experimental Other
Control,High intensity interval training (HIIT),Asparagus root extract supplementation (ARE),HIIT combined ARE

Sponsors

Burapha University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: 1) Male or female aged 18-30 years 2) Having body mass index more than 23.0 kg/m2 3) Practice exercise or sport training less than 75 min/week

Exclusion criteria

Exclusion criteria: 1) Daily supplementation with drugs or diets 2) Having food or drug allergy i.e., asparagus 3) Regular smoking (> 30 packs-years) 4) Regular alcohol drinking (>1 cup/day) 5) Having drugs or diseases of cardiovascular, respiratory, liver, renal, endocrine, musculoskeletal, infectious, cancer, neurological, or psychiatric disease

Design outcomes

Primary

MeasureTime frame
Inflammatory biomarkers Baseline and post-intervention Intravenous blood sample will be collected for analyzing inflammation (IL-6 protein, TNF-alpha protein).

Secondary

MeasureTime frame
Muscle thickness Baseline and post-intervention The B-mode ultrasonography will be used to capture quadricepts muscle images of the dominant leg. All muscle thickness (MT) and echo intensity (EI) were analyzed with Image J software.,Endothelium-dependent vasodilation Baseline and post-intervention Post-occlusive reactive hyperemia (PORH) technique will be used at brachial artery at the dominant arm. ,muscle strengthening Baseline and post-intervention Upper arm strengthening will be measured by the bench press technique. Leg dynamometer test will be used to evaluate leg muscles strengthening.,Body composition and anthropometry Baseline, during, post-intervention Body composition (body mass, BMI, muscle mass, %body fat, fat mass, water mass, protein mass, mineral mass, bone mass, and visceral fat level) will be measured by a bioelectrical impedance analyzer.,Vital sign Baseline, during, post-intervention HR, blood pressure (BP), BP variability, respiratory rate (RR), and partial oxygen saturation (SpO2) will be measured in the supine position by a bed side monitor,Physical activity level and dietary intake Baseline, during, post-intervention The Beacke Habitual Physical Activity Questionnaire will be used to determine activity levels. The 24 hrs. dietary recall and Food Frequency Questionnaires will be used to determine dietary intake.

Countries

Thailand

Contacts

Public ContactPiyapong Prasertsri

Burapha university

piyapong@buu.ac.th038103166

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026