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Mitochondrial dysfunction in PBMCs is associated with the severity of liver fibrosis in patients after the Fontan operation

Mitochondrial dysfunction in PBMCs is associated with the severity of liver fibrosis in patients after the Fontan operation

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20230601009
Enrollment
31
Registered
2023-06-01
Start date
2021-07-07
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fontan patients Fontan operation mitochondrial function liver biopsy liver fibrosis cirrhosis

Interventions

Fontan patients without known underlying liver disease
Diagnostic
Fontan patients

Sponsors

The National Research Council of Thailand
Lead Sponsor
Faculty of medicine, Chiang Mai University
Collaborator

Eligibility

Sex/Gender
All
Age
15 Years to No maximum

Inclusion criteria

Inclusion criteria: - Fontan patients without known underlying liver diseases and age more than 15 years - Give inform consent

Exclusion criteria

Exclusion criteria: - Known case underlying liver diseases

Design outcomes

Primary

MeasureTime frame
Mitochondrial function 1 day Mitochondrial level

Secondary

MeasureTime frame
Echocardiography 1 day Systemic ventricular function,Computerized tomography scan of upper abdomen 1 day Liver parenchymal and nodular abnormalities,Ultrasound of upper abdomen 1 day Liver parenchymal and nodular abnormalities,Magnetic resonance imaging of upper abdomen 1 day Liver parenchymal and nodular abnormalities,Magnetic resonance elastography 1 day Liver parenchymal and nodular abnormalities,Ultrasound liver elastography 1 day Liver parenchymal and nodular abnormalities,Cardiac catheterization 1 day Hemodynamic study,Stool gut microbiota 1 day microbiota,Holter 1 day Arrhythmia

Countries

Thailand

Contacts

Public ContactSaviga Sethasathien

Faculty of Medicine, Chiang Mai University

micro.cardioped@gmail.com0823905554

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026