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Tetracaine eye drops as a preemptive topical skin anesthesia for botulinum toxin type A injections in blepharospasm patients: a randomized controlled trial

Tetracaine eye drops as a preemptive topical skin anesthesia for botulinum toxin type A injections in blepharospasm patients: a randomized controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20230530007
Enrollment
17
Registered
2023-05-30
Start date
2023-11-16
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The patients with confirmed diagnosis of blepharospasm, who undergo botulinum toxin A treatment in botulinum toxin clinic. Department of Ophthalmology, King Chulalongkorn Memorial Hospital Botulinum toxin, Blepharospasm, Pain, Tetracaine

Interventions

The control side received a U shape cotton pad soaked with 5 ml of Normal saline was applied on the skin 30 minute and cover with plastic wrap prior to the botulinum toxin injection,The experimental
NSS,Tetracaine

Sponsors

Faculty of medicine, Chulalongkorn University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients of age more than 18 years 2. Diagnosed with Blepharospasm both eye by experienced neuro-ophthalmologists 3. Received the latest BoNT-A injection for more than 3 months

Exclusion criteria

Exclusion criteria: 1. Allergic reaction to Botulinum toxin type A 2. Neuromuscular diseases 3. Any active infection in treatment area 4. Receiving anticoagulants 5. Diagnosed with bleeding disorders 6. Patients undergone prior facial cosmetic surgical procedure, such as eyebrow lift and others periorbital surgery 7. Patients with psychological disease 8. Patients with different severity of Blepharospasm

Design outcomes

Primary

MeasureTime frame
Pain score After finish intervention a numeric rating scale (NRS)

Secondary

MeasureTime frame
Complication after application tetracaine eye drops as a topical skin anesthesia After finish intervention 30 min Assess complication after application tetracaine eye drops as a topical skin anesthesia

Countries

Thailand

Contacts

Public ContactNavinda Pinitpanich

King Chulalongkorn Memorial Hospital

navinda607.19@gmail.com0911302560

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026