The Effect of Closure Technique and Postoperative Socket Irrigation on Postoperative Complications After Impacted Mandibular Third Molar Surgery: A Randomized Controlled Trial

Status

Unknown

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230517005

Enrollment

Registered

2023-05-17

Start date

2022-10-10

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative complications after impacted mandibular third molar surgery in healthy human volunteers Socket irrigation Closure techniques Postoperative complications Impacted mandibular third molar

Interventions

standard post-operative care and primary closure,standard post-operative care and secondary closure,post-operative irrigation and primary closure,post-operative irrigation and secondary closure

No Intervention Procedure/Surgery,Experimental Procedure/Surgery,Experimental Procedure/Surgery,Experimental Procedure/Surgery

Eligibility

Sex/Gender

All

Age

15 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Patients who have non-infected impacted mandibular third molar 2. Patients who have moderate difficult impacted mandibular third molar according to Pedersons difficulty index 3. Patients who have level A or B depth impacted mandibular third molar 4. Age between 15 to 35 years old 5. Patients who have American Society of Anesthesiologist (ASA) class I or II

Exclusion criteria

Exclusion criteria: 1. Patients who have more than 5 mm periodontal pocket or dental caries at distal site of adjacent mandibular second molar 2. Smoker, alcoholic, cannabis user or drug abuser 3. On drug therapy that may interfere with healing after the surgery such as glucocorticoid steroids, nonsteroidal anti-inflammatory drugs, or antibiotics 4. Pregnant women, lactating women, and patients who take oral estrogen-containing contraceptive drugs 5. Patients who have blood disorders such as Thalassemia or G6PD deficiency 6. Psychiatric patients 7. Patients who cannot participate in the study and postoperative follow-up 8. Patients who cannot follow the postoperative instructions

Design outcomes

Primary

Measure	Time frame
Pain intensity 7 Days after surgery Visual analog scale,Maximum mouth opening 7 Days after surgery millimeter,Swelling 7 Days after surgery craniometric method (millimeter),Sign of infection 30 Days after surgery presence of parameter	—

Secondary

Measure	Time frame
Post-op complication 30 Days after surgery presence of parameter	—

Countries

Thailand

Contacts

Public ContactGun Kraisittisirikul

Faculty of Dentistry, Chulalongkorn University

gunnkraisittisirikul@gmail.com0879803311

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026