Pulmonary artery hypertension in systemic sclerosis patients Systemic sclerosis Pulmonary artery hypertension Inhaled nitrite Mean pulmonary artery pressure
Conditions
Interventions
None listed
Sponsors
Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Systemic sclerosis patients with and without interstitial lung disease. 2. Patients in clinically stable state 3. Do not receive medication which affect platelet function (NSAIDs or anti-platelet drugs) within 2 weeks. 4. Patients who were nonsmokers, not drinking alcohol and not addicting illegal drugs.
Exclusion criteria
Exclusion criteria: 1. The use of organic nitrate and pulmonary vasodilator agents (calcium channel blockers or endothelin receptor antagonists) other than sildenafil. 2. Patients with systolic blood pressure lower than 100 mmHg and/or diastolic blood pressure lower than 70 mmHg 3. Patients with hematocrit lower than 24% 4. Patients with methemoglobin greater than 1% 5. Patients who taking antiplatelet medications. 6. Patients who smoking, drinking alcohols and being a drug addiction. 7. Patients with glomerular filtration rate lower than 60 mL/min/1.73 m2 8. Patients with severe co-morbidities (heart failure, ischemic heart diseases, COPD, diabetes mellitus, thyroid disease, chronic kidney disease) 9. Pregnant patients 10. Patient who denied or withdrawn from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean pulmonary artery pressure Every 1 min during intrite inhalation Transthoracic echocardiogram | — |
Secondary
| Measure | Time frame |
|---|---|
| Max tricuspid valve regurgitation velocity Every 1 min during intrite inhalation Transthoracic echocardiogram | — |
Countries
Thailand
Contacts
Public ContactNathawut Sibmooh
Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand
Outcome results
None listed