Comparative postoperative pain control effect of dexamethasone use between preemptive and intraoperative: A Triple-Blind, Randomized, Placebo-Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230516011

Enrollment

150

Registered

2023-05-16

Start date

2022-01-03

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty in primary osteoarthritis of knee Total knee arthroplasty, Dexamathasone, Pre-emptive analgesia, Post-operative pain control, Primary osteoarthitis of knee,

Interventions

Dexamethasone group will receive - Dexamethasone (10 mg) (0.11-0.2 mg/kg) at least 8 hours before surgery - Placebo (NSS 50 ml) during surgery after successful spinal block anesthesia. Dexamethasone

Active Comparator Drug,Placebo Comparator No treatment

Dexamethasone,Placebo

Eligibility

Sex/Gender

All

Age

55 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patient on going to perform unilateral total knee arthroplasty from primary osteoarthritis 2. Age 55-80 years 3. Body weight 50-90 kilograms 4. Suitable to use spinal anesthesia for intra-operative pain control 5. ASA Classification 1-3 6. Agree to attend in this study

Exclusion criteria

Exclusion criteria: 1. History of using corticosteroid drug in 3 months 2. History of using immunosuppressive drug in 3 months 3. History of using strong opioid in 7 days 4. Suspect infection in any site 5. History of allergy drug use in this study (Dexamethasone, opioid group, tranexamic acid, paracetamol, lorazepam, omeprazole) 6. Have underlying disease include diabetes mellitus, gastric ulcer, severe heart disease, liver failure, renal failure 7. Not co-operate to treatment 8. Denied to attend in study

Design outcomes

Primary

Measure	Time frame
Pain Post operative at 4h, 8h, 12h, 16h, 20h, 24h, 30h, 36h, 42h, 48h Visual analog score	—

Secondary

Measure	Time frame
Knee circumference Post operative at 12h, 24h, 36h, 48h centimeter,Inflammatory marker Post operative at 24h, 48h C-reactive protein(CRP),blood glucose Post operative at 12h, 24h, 36h, 48h Capillary blood glucose,Morphine consumption With in 48h post operative Record amount of morphine use via patient controlled analgesia	—

Countries

Thailand

Contacts

Public ContactKritsanat Lertussavavivat

Buddhachinaraj Phitsanulok Hospital, Thailand

nalomoly@gmail.com0876946571

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026