Effectiveness and Safety of Platelet-Rich Plasma in Restoration of the Skin in Periorbital Areas, Frontal Hairline, and Eyebrows

Status

Unknown

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230516004

Enrollment

Registered

2023-05-16

Start date

2023-04-25

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Androgenetic Alopecia at hairline with mild to moderate wrinkle at periorbital Leukocyte poor Platelet-rich plasma, Restoration of the Skin in Periorbital Areas, Frontal Hairline, and Eyebrows

Interventions

Patients were treated with Platelet-rich plasma 3 sessions every 4 weeks. Then they were instructed to follow up at 1 month, 3 months, 6 months after the last treatments.

Experimental Device

Platelet-Rich Plasma

Eligibility

Sex/Gender

All

Age

35 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 35-65 years 2. Both men and women 3. Mild to advanced photoaging by Glogau classification group I-III 4. Androgenetic Alopecia by dermoscopic criteria

Exclusion criteria

Exclusion criteria: 1. Pregnancy or lactation 2. Participants with using cream that affect wrinkle or colors or with antioxidant ingredients within 1 month before joining research 3. Participants with treatment like laser, filler or botulinum toxin injection within 3 month before joining research 4. Participants with history of low platelet or coagulopathy or taking medicine that interfere the coagulation like warfarin 5. Participants with needle phobia 6. Participants with history of allergy to anesthesia drug or sodium citrate 7. Participants with underlying disease of connective tissue diseases, autoimmune disease, immunosuppressive host or kelod 8. Participants with any psychological problem

Design outcomes

Primary

Measure	Time frame
Physician improvement scale Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks Physician global aesthetic improvement scale	—

Secondary

Measure	Time frame
Patient improvement scale Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks Physician global aesthetic improvement scale,Skin Texture Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks Antera,Skin Wrinkle Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks Antera,Skin elasticity Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks Cutometer,Melanin and Erythema Index Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks Mexameter,Physician global improvement at eyebrow Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks 7-Point grading scale,Physician global improvement at periorbital Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks 7-Point grading scale,Target area hair count baseline, 24 weeks, 36 weeks Trichoscan	—

Measure

Time frame

Patient improvement scale Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks Physician global aesthetic improvement scale,Skin Texture Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks Antera,Skin Wrinkle Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks Antera,Skin elasticity Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks Cutometer,Melanin and Erythema Index Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks Mexameter,Physician global improvement at eyebrow Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks 7-Point grading scale,Physician global improvement at periorbital Baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks 7-Point grading scale,Target area hair count baseline, 24 weeks, 36 weeks Trichoscan

—

Countries

Thailand

Contacts

Public ContactSasima Eimpunth

Faculty of Medicine Siriraj Hospital, Mahidol University

doctorsasima@gmail.com66858303555

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026