Proton Pump Inhibitor Refractory Functional Dyspepsia patients Functional dyspepsia, Vonoprazan, Global Overall Symptom scale, Nepean Dyspepsia Index, Hospital Anxiety and Depression scale
Conditions
Interventions
The participant will receive Vonoprazan 20 mg per day for 28 days,The participant will receive Vonoprazan 10 mg per day for 28 days
Experimental Drug,Experimental Drug
Vonoprazan 20 mg,Vonoprazan 10 mg
Sponsors
Rajavithi Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age greater than 18 years old, 2.Diagnosed functional dyspepsia by ROME IV criteria with persistent symptoms after four-week duration of standard dose Proton Pump Inhibitor, 3.No significant Gastroduodenal lesions such as no gastric ulcer, no duodenal ulcer and no gastroduodenal neoplasm by Esophagogastroduodenoscopy 4.Negative for H.pylori test for at least 3 months
Exclusion criteria
Exclusion criteria: 1. Severe or uncontrolled co-morbidities such as chronic liver disease, end stage renal disease, chronic lungs disease, heart disease and cancer 2. On pregnancy or on lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Dyspepsia Symptoms at 2 weeks and 4 weeks after received the intervention Global Overall Symptom Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional Dyspepsia Quality of Life at 2 weeks and 4 weeks after received the intervention The Short form Nepean Dyspepsia Index,Frequency of rescue medication at 2 weeks and 4 weeks after received the intervention Patient reported outcome using a questionnaire interview,Safety and adverse events at 2 weeks and 4 weeks after received the intervention Patient reported outcome using a questionnaire interview | — |
Countries
Thailand
Contacts
Public ContactPantaree Jaigla
Rajavithi Hospital
Outcome results
None listed