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Golden Rice Cookies with red betle leaf: A Tasty and Effective Biomolecular Solution for Preventing Diabetic Foot Ulcers

Targeting MMP-9 with Golden Rice-based Cookies Containing Piper crocatum: A Novel Biomolecular Intervention for Preventing Diabetic Foot Ulcers

Status
Unknown
Phases
Early Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20230502001
Enrollment
60
Registered
2023-05-02
Start date
2023-06-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The study population consists of outpatients from wound care clinics in Makassar, Indonesia, diagnosed with Diabetes Mellitus, with increased risk neuropathy status on monofilament test examination, and ankle brachial index value above 0.9. diabetic foot ulcer, complementary therapy, cookies, golden rice, piper crocatum ruiz and pav, MMP-9

Interventions

The participants will consume cookies three times a day for 28 days. The researchers will conduct follow-up monofilament tests and random blood sugar tests on days 7, 14, and 21, and will collect samp
Experimental Dietary Supplement,Placebo Comparator Dietary Supplement
Intervention group,Control group

Sponsors

Institute for Research and Community Service of Hasanuddin University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients diagnosed with Diabetes Mellitus, with increased risk neuropathy status on monofilament test examination, and ankle brachial index value > 0.9.

Exclusion criteria

Exclusion criteria: Patients suffering from diabetic foot ulcer.

Design outcomes

Primary

MeasureTime frame
Matrix metalloproteinase-9 at 28 days after end of the intervention Western blotting

Secondary

MeasureTime frame
neuropathy score, blood glucose level day 0, 7, 14, 21, 28 at cookies consumption Michigan neuropathy instrument, one touch blood glucose, monofilament test

Countries

Indonesia

Contacts

Public ContactAndina Setyawati

Hasanuddin University

andina@unhas.ac.id628121521639

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026