The first group: Healthy volunteers The second group: Patients with cardiovascular risk factors, dyslipidemia The third group: Patients with chronic coronary syndrome undergoing coronary angiography 1. Healthy volunteers 2. Patients with cardiovascular risk factors, dyslipidemia 3. Patients with chronic coronary syndrome undergoing coronary angiography
Conditions
Interventions
1. Volunteers must be 35-70 years old
2. Volunteers must not have any of the following risk factors for cardiovascular disease
- Dyslipidemia
- Type 2 diabetes mellitus
- Hypertension
- Obesity
- Meta
Healthy volunteers,Patients with cardiovascular risk factors, dyslipidemia,Patients with chronic coronary syndrome undergoing coronary angiography.
Sponsors
Faculty of Medicine, Srinakharinwirot University
Eligibility
Sex/Gender
All
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: The first group: Healthy volunteers 1. Volunteers must be 35-70 years old 2. Volunteers must not have any of the following risk factors for cardiovascular disease - Dyslipidemia - Type 2 diabetes mellitus - Hypertension - Obesity - Metabolic syndrome. 3. Volunteers must not have acute coronary syndrome or chronic coronary syndrome 4. Volunteers are willing to participate in the research by signing the consent forms The second group: Patients with cardiovascular risk factors, dyslipidemia 1. Volunteers must be 35-70 years old 2. Volunteers must have a risk factor for cardiovascular disease, dyslipidemia 3. Volunteers must not have any of the following risk factors for cardiovascular disease - Type 2 diabetes mellitus - Hypertension - Obesity - Metabolic syndrome. 4. Volunteers are willing to participate in the research by signing the consent forms. The third group: Patients with chronic coronary syndrome undergoing coronary angiography 1. Volunteers must be 35-70 years old 2. Volunteers with chronic coronary syndrome undergoing coronary angiography Chronic coronary syndrome patients refer to the patients with angina pectoris due to demand-supply mismatch which cause myocardial ischemia. Coronary anatomy is greater than 70% stenosis in coronary arteries that are larger than 2.5 mm in one view of coronary angiogram, greater than 50% stenosis in coronary arteries in more than two views of coronary angiogram and greater than 50% stenosis in the left main coronary artery. 3. Volunteers are willing to participate in the research by signing the consent forms
Exclusion criteria
Exclusion criteria: 1. Volunteers with underlying disease including chronic kidney disease (eGFR < 60 ml/min/1.73 m2 for more than 3 months), liver disease (AST/ALT > 5 times normal or jaundice), cancer, intestinal diseases such as inflammatory bowel disease, thyroid dysfunction, immunodeficiency such as human immunodeficiency virus (HIV) 2. Volunteers who take antibiotics, immunosuppressants, probiotics supplement, synbiotics, herbal supplements, antacids or laxatives within 4 weeks before participating in the study 3. Volunteers who have history of gastrointestinal disease and other infections within 4 weeks 4. Volunteers who smoke 5. Volunteers with alcoholism 6. Volunteers who are pregnant or lactating 7. Volunteers who have Covid-19 infection within 4 weeks 8. Volunteers who refuse to participate in the research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota composition and related parameters At 12 months after end of the intervention Illumina MiSeq, analyzed with UCLUST from QIIME 2 2019.10 software in conjunction with the Zymo database | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiota diversity At 12 months after end of the intervention Illumina MiSeq, analyzed with UCLUST from QIIME 2 2019.10 software in conjunction with the Zymo database,Influence of dietary habits on gut microbiota profiles At 12 months after end of the intervention Illumina MiSeq, analyzed with UCLUST from QIIME 2 2019.10 software in conjunction with the Zymo database | — |
Countries
Thailand
Contacts
Public ContactWongsakorn Luangphiphat
Faculty of Medicine, Srinakharinwirot University
Outcome results
None listed